Precursor to metabolite: Risperidone LAI to Paliperidone

Risperidone LAI is converted to Paliperidone by CYP2D6.

The pair

Risperidone LAI — Subcutaneous long-acting risperidone for schizophrenia; no oral supplementation after injection.
Paliperidone — Active metabolite of risperidone; extended-release oral and long-acting injectables.

Anything that inhibits or induces CYP2D6 shifts the balance between Risperidone LAI and Paliperidone.