Precursor to metabolite: Risperidone LAI (RISPERDAL CONSTA) to Paliperidone

Risperidone LAI is converted to Paliperidone by CYP2D6.

The pair

Risperidone LAI — Microsphere antipsychotic depot; delayed release requires oral overlap and relatively frequent injections.
Paliperidone — Active metabolite of risperidone; extended-release oral and long-acting injectables.

Anything that inhibits or induces CYP2D6 shifts the balance between Risperidone LAI and Paliperidone.