Precursor to metabolite: Palopegteriparatide to Teriparatide

Palopegteriparatide is converted to Teriparatide by TransCon linker autocleavage.

The pair

Palopegteriparatide — Long-acting PTH-receptor agonist replacing deficient hormone in chronic hypoparathyroidism.
Teriparatide — Recombinant PTH fragment; anabolic (bone-building) osteoporosis drug.