Precursor to metabolite: Oxycodone CR to Oxymorphone
Oxycodone CR is converted to Oxymorphone by CYP2D6.
The pair
- Oxycodone CR — Controlled-release oxycodone for continuous severe chronic pain; misuse risk persists.
- Oxymorphone — Potent semisynthetic mu-opioid agonist; little CYP dependence but full overdose liability.
Anything that inhibits or induces CYP2D6 shifts the balance between Oxycodone CR and Oxymorphone.
Oxycodone CR · Oxymorphone · Open Oxycodone CR in the interactive console ↗