Precursor to metabolite: Nabumetone to 6-MNA

Nabumetone is converted to 6-MNA by hepatic oxidation.

Nabumetone mascot — mnemonic cartoon — Nabumetone — mascot

The pair

Nabumetone — COX-2-preferring NSAID prodrug.
6-MNA — Active nabumetone metabolite, 6-methoxy-2-naphthylacetic acid; provides NSAID effects and associated GI, renal, and cardiovascular risks.

Nabumetone · 6-MNA · Open Nabumetone in the interactive console ↗