Precursor to metabolite: Fostemsavir to Temsavir

Fostemsavir is converted to Temsavir by alkaline phosphatase.

The pair

Fostemsavir — gp120 attachment-inhibitor prodrug for heavily treatment-experienced multidrug-resistant HIV.
Temsavir — Active fostemsavir metabolite that binds HIV gp120 and blocks attachment; used in regimens for heavily treatment-experienced patients.