Precursor to metabolite: Acetaminophen to NAPQI

Acetaminophen is converted to NAPQI by CYP2E1.

Acetaminophen mascot — mnemonic cartoon — Acetaminophen — mascot

The pair

Acetaminophen — OTC analgesic/antipyretic; hepatotoxic in overdose, minimal anti-inflammatory effect.
NAPQI — Reactive acetaminophen metabolite normally detoxified by glutathione; glutathione depletion permits severe liver injury.

Acetaminophen · NAPQI · Open Acetaminophen in the interactive console ↗