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Y2 agonist

• Presynaptic autoreceptor — feedback inhibition of NPY and noradrenaline release
• Contrasts with postsynaptic Y1, which mediates anxiolysis and vasoconstriction
• Appetite and energy-balance signaling from the arcuate nucleus

Drugs with this mechanism (1)

• Neuropeptide Y — Abundant CNS peptide; a powerful stimulant of appetite.

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