Y2 agonist
Neuropeptide Y2 receptor agonist
- Presynaptic NPY autoreceptors
- Feedback inhibition of NPY and norepinephrine release
- Roles in appetite/energy balance
- Signaling from the arcuate nucleus
- Opposes postsynaptic Y1 signaling
- Y1 mediates anxiolysis and vasoconstriction
Drugs with this mechanism (2)
- Neuropeptide Y — Abundant CNS peptide; powerful appetite stimulant.
- PYY (3-36) — Ileal-brake satiety peptide acting at Y2 — NPY’s counterpart.
Self-check
- Which two transmitters’ release is inhibited by Y2 feedback?
NPY and norepinephrine. - Which postsynaptic receptor’s signaling does Y2 oppose?
Y1.
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