Vitamin D receptor agonist
- ↑ intestinal calcium/phosphate absorption
- ↓ PTH
- Treats hypocalcemia, renal osteodystrophy and psoriasis (topical)
- Excess → hypercalcemia
Drugs with this mechanism (3)
- Calcipotriene — Vitamin D analog for psoriasis; normalizes keratinocyte proliferation.
- Calcitriol — Active vitamin D and VDR agonist.
- Paricalcitol — Selective vitamin-D receptor agonist for secondary hyperparathyroidism in CKD.
Self-check
- How does vitamin-D-receptor activation affect PTH?
Decreases it. - What calcium abnormality can excessive activation cause?
Hypercalcemia.
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