Venous sclerosant
Detergent sclerosant — venous endothelial membrane disruption
- Non-ionic detergent: its hydrophobic tail lodges in the endothelial lipid membrane, the osmotic barrier fails and the endothelium is destroyed
- Vasospasm and a thrombogenic surface follow; the vein occludes and is replaced by fibrous tissue
- Deactivated on contact with blood, so the action stays at the injected segment — injected as 1% foam (VARITHENA) or 0.5%/1% solution (ASCLERA)
Drugs with this mechanism (1)
- Polidocanol — Detergent sclerosant injected into varicose veins (foam, VARITHENA; solution, ASCLERA): destroys the endothelium so the vein occludes and fibroses.
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