URAT1 inhibitor

URAT1 urate transporter inhibitor

Increases renal uric acid excretion
Ineffective in renal impairment; raises stone risk
Blocks tubular secretion of many drugs

Drugs with this mechanism (2)

Lesinurad — Uricosuric add-on to a xanthine oxidase inhibitor for gout; kidney-injury risk and discontinued U.S. marketing.
Probenecid — Uricosuric for gout; also blocks renal drug excretion (used to boost antibiotics).

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