URAT1 inhibitor
URAT1 urate transporter inhibitor
- ↓ renal urate reabsorption
- ↑ urinary uric-acid excretion → lowers serum urate
- Ineffective in renal impairment
- Uricosuria raises kidney-stone risk — hydrate and alkalinize
- Blocks tubular secretion of many drugs
Drugs with this mechanism (2)
- Lesinurad — Uricosuric add-on to a xanthine oxidase inhibitor for gout; kidney-injury risk and discontinued U.S. marketing.
- Probenecid — Uricosuric for gout; also blocks renal drug excretion (used to boost antibiotics).
Self-check
- Why hydrate and alkalinize during uricosuric treatment?
Increased kidney-stone risk. - When is this urate-transporter strategy ineffective here?
Renal impairment.
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