Clinical effect established; the molecular target is not
Pyrazinamide is the library’s one genuine unknown: fatty-acid synthase I, ribosomal trans-translation and membrane depolarization by pyrazinoic acid all have support, and none is settled
Drugs with this mechanism (1)
Pyrazinamide — First-line tuberculosis drug whose mechanism is genuinely contested — fatty-acid synthase I, ribosomal trans-translation, and membrane depolarization by pyrazinoic acid all have support, none settled; hepatotoxicity and hyperuricemia limit it.