TTR stabilizer
Transthyretin (TTR) tetramer stabilizer
- Prevents tetramer dissociation into amyloid
- Slows ATTR cardiomyopathy and polyneuropathy
- Stabilizes existing protein rather than reducing its production
Drugs with this mechanism (2)
- Acoramidis — Oral transthyretin stabilizer; holds the TTR tetramer together in ATTR cardiomyopathy.
- Tafamidis — Stabilizes the transthyretin tetramer in ATTR cardiomyopathy.
Self-check
- Which structural event does TTR stabilization prevent?
Tetramer dissociation. - Does TTR stabilization reduce production of the protein?
No; it stabilizes existing protein.
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