TTR silencer (siRNA)
Transthyretin (TTR) silencer (siRNA)
- Silences the transthyretin (TTR) gene via RNA interference
- ↓ TTR production → less amyloid formation in ATTR amyloidosis
- Lowers the amyloid precursor at its source, unlike tetramer stabilizers
Drugs with this mechanism (1)
- Vutrisiran — siRNA that silences transthyretin production — the opposite strategy to stabilizing it.
Self-check
- What silencing process reduces transthyretin production?
RNA interference. - How does this differ from TTR tetramer stabilization?
Lowers the amyloid precursor at its source.
All mechanisms · Open TTR stabilizer in the interactive console ↗