TRPM8 agonist
TRPM8 cold-receptor agonist
- Ocular activation stimulates tear production → treats dry-eye disease
- The receptor menthol also activates — the “cooling” sensation
Drugs with this mechanism (1)
- Acoltremon — TRPM8 "cold receptor" agonist eye drop; triggers the eye’s own tear reflex.
Self-check
- What ocular effect of TRPM8 activation treats dry eye?
Increased tear production. - Which familiar cooling substance also activates TRPM8?
Menthol.
All mechanisms · Open TRPM8 agonist in the interactive console ↗