Injected collagenase
- Enzymatically cleaves pathologic collagen cords
- Breaks Dupuytren contractures and Peyronie plaques without surgery
- Local action only
- Tendon rupture if injected outside the cord
Drugs with this mechanism (1)
- Collagenase clostridium histolyticum — Injected bacterial collagenase that dissolves the cord in Dupuytren and Peyronie disease.
Self-check
- Which contractures can collagenase break without surgery?
Dupuytren contractures. - What can follow injection outside the collagen cord?
Tendon rupture.
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