TGF-beta inhibitor
TGF-beta signaling inhibitor
- ↓ fibroblast activation and matrix deposition → slows pulmonary fibrosis
- Photosensitivity and GI upset
Drugs with this mechanism (1)
- Pirfenidone — Antifibrotic for idiopathic pulmonary fibrosis.
Self-check
- What cellular process is reduced to slow pulmonary fibrosis?
Fibroblast activation and matrix deposition. - Which light-related adverse effect accompanies this mechanism?
Photosensitivity.
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