TAAR1 agonist

Trace amine-associated receptor 1 agonist

Modulates dopamine and glutamate signaling indirectly

Drugs with this mechanism (3)

Phenethylamine — Endogenous trace amine and the structural core of the amphetamines.
Tyramine — Dietary trace amine that triggers hypertensive crisis with MAOIs.
Ulotaront — Investigational TAAR1/5-HT1A agonist for schizophrenia without D2 blockade; phase 3 efficacy findings have been disappointing.

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