TAAR1 agonist
Trace amine-associated receptor 1 agonist
- Indirectly modulates dopamine and glutamate — a proposed antipsychotic effect WITHOUT D2 blockade
- Efficacy unproven: ulotaront’s phase 3 schizophrenia trials did not separate from placebo
- No EPS or prolactin rise
Drugs with this mechanism (3)
- Phenethylamine — Endogenous trace amine and the structural core of the amphetamines.
- Tyramine — Dietary trace amine that triggers hypertensive crisis with MAOIs.
- Ulotaront — Investigational TAAR1/5-HT1A agonist for schizophrenia without D2 blockade; phase 3 efficacy findings have been disappointing.
Self-check
- Does the proposed TAAR1 antipsychotic mechanism require D2 blockade?
No. - Did ulotaront’s phase 3 schizophrenia trials separate from placebo?
No; efficacy remains unproven.
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