Somatostatin receptor agonist
- Suppresses growth hormone and multiple GI/pancreatic hormones
- Treats acromegaly, neuroendocrine tumors and variceal bleeding
- Gallstones and glucose dysregulation from broad secretory suppression
Drugs with this mechanism (3)
- Lanreotide — Long-acting somatostatin analog for acromegaly and neuroendocrine tumors.
- Octreotide — Somatostatin analog for acromegaly, neuroendocrine symptoms, variceal bleeding, and secretory diarrhea.
- Paltusotine — Oral somatostatin-receptor agonist for acromegaly; avoids depot injections.
Self-check
- Which pituitary hormone is suppressed by somatostatin agonists?
Growth hormone. - Which biliary complication results from broad secretory suppression?
Gallstones.
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