SMO antagonist
Smoothened (SMO) antagonist — hedgehog pathway
- Shuts off aberrant Hedgehog drive → ↓ basal cell carcinoma
- Blocks Smoothened
- Muscle spasms, dysgeusia, alopecia and teratogenicity are class effects
Drugs with this mechanism (1)
- Vismodegib — Oral Smoothened inhibitor for unresectable or metastatic basal-cell carcinoma; profoundly teratogenic.
Self-check
- Which skin cancer is treated by shutting off aberrant Hedgehog drive?
Basal-cell carcinoma. - Which fetal risk accompanies SMO antagonism?
Teratogenicity.
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