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Sigma-2 agonist

• σ2 activation can promote mitochondrial dysfunction, and pro-apoptotic signaling
• Potentially neurotoxic under stress conditions

Drugs with this mechanism (3)

• Haloperidol — Prototypical high-potency typical antipsychotic; potent D2 blocker, high EPS risk.
• Haloperidol decanoate LAI — First-generation D2-antagonist depot for schizophrenia maintenance; EPS burden is high.
• Haloperidol injection — Parenteral high-potency D2 antipsychotic for acute agitation; IV use magnifies QT concern.

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