sGC stimulator
Soluble guanylate cyclase stimulator
- Sensitizes the enzyme to nitric oxide and stimulates it directly — ↑ cGMP even when NO is low
- Vasodilation in pulmonary and systemic vessels
- Synergistic hypotension with nitrates and PDE5 inhibitors — never combine
Drugs with this mechanism (2)
- Riociguat — Soluble guanylate cyclase stimulator for pulmonary hypertension.
- Vericiguat — Soluble guanylate cyclase stimulator for worsening heart failure.
Self-check
- Can sGC stimulation increase cGMP when NO is low?
Yes; it also stimulates the enzyme directly. - Why must these stimulators not be combined with nitrates or PDE5 inhibitors here?
Synergistic hypotension.
All mechanisms · Open Soluble guanylate cyclase (sGC) stimulator in the interactive console ↗