VEGF decoy receptor (VEGF trap)

A soluble receptor that catches the ligand before the real one can

Fusion of VEGFR-1/2 binding domains on an Fc backbone — binds VEGF-A, VEGF-B and PlGF with sub-picomolar affinity
Traps the ligand in solution; vessel growth and leak signaling never start
➔ aflibercept (EYLEA intravitreal; ZALTRAP IV in oncology) ⚠ confirm ZALTRAP mention wanted
Same axis as the anti-VEGF mAbs (ranibizumab, faricimab) — different molecular strategy

Drugs with this mechanism (1)

Aflibercept — Intravitreal VEGF decoy receptor for macular degeneration and retinal edema.

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