TNF decoy receptor
TNF-alpha decoy receptor
- Anti-inflammatory across rheumatoid arthritis and psoriasis
- Decoy receptor binding TNF-alpha
- Immunosuppression → infection and TB reactivation risk — screen first
Drugs with this mechanism (1)
- Etanercept — Soluble TNF receptor-Fc decoy; mops up TNF-α and lymphotoxin-α, unlike the anti-TNF antibodies.
Self-check
- What molecular strategy captures TNF-alpha here?
A decoy receptor. - Which latent infection requires screening before treatment?
Tuberculosis.
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