Methotrexate inactivation (enzymatic)
Methotrexate inactivation (glucarpidase)
- Enzyme cleaves methotrexate into inactive metabolites
- Rapidly clears toxic methotrexate levels in renal impairment
- Interferes with methotrexate assays
- Reduced-folate rescue must be timed apart
Drugs with this mechanism (1)
- Glucarpidase — Enzyme rapidly breaking down circulating methotrexate in delayed clearance with kidney dysfunction; does not replace leucovorin rescue.
Self-check
- In which organ impairment does enzymatic methotrexate removal provide rescue?
Renal impairment. - What rescue therapy must be timed apart?
Reduced-folate rescue.
All mechanisms · Open Methotrexate sequestrant in the interactive console ↗