Lipid sink sequestrant
- Creates an intravascular lipid compartment
- Sequesters lipophilic drugs out of tissue → rescue for local-anesthetic toxicity
Drugs with this mechanism (1)
- IV lipid emulsion — Intravenous lipid-sink rescue for severe local-anesthetic systemic toxicity.
Self-check
- Where does lipid rescue create a new drug compartment?
Intravascularly. - Which toxicity is rescued by sequestering lipophilic drug from tissues?
Local-anesthetic toxicity.
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