Iron chelator
Iron sequestrant
- Chelates free/excess iron into excretable complexes
- Treats iron-overload states and acute iron poisoning
- Removes only the toxic iron burden, not iron in hemoglobin
Drugs with this mechanism (3)
- Deferasirox — Oral iron chelator for chronic transfusional iron overload; renal, hepatic, and GI toxicity.
- Deferiprone — Oral iron chelator for transfusional iron overload; potentially fatal agranulocytosis requires neutrophil monitoring.
- Deferoxamine — Injectable iron chelator for acute iron poisoning and chronic overload; prolonged therapy can damage hearing and vision.
Self-check
- Does systemic iron chelation remove hemoglobin iron here?
No. - Name a listed systemic iron chelator.
Deferoxamine.
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