Iron chelator (cardioprotection)

Iron chelation — anthracycline cardioprotection

Chelates intracellular iron → prevents anthracycline-iron free-radical formation
Cardioprotection during anthracycline therapy; also inhibits topoisomerase II
Distinct from systemic iron-overload chelators

Drugs with this mechanism (1)

Dexrazoxane — Iron-chelating cardioprotectant for anthracyclines; a separate use rescues anthracycline extravasation.

All mechanisms · Open the interactive console ↗