Heparin sequestrant
- Positive charge binds and neutralizes negatively charged heparin
- Immediate reversal of unfractionated heparin anticoagulation
- Reversal is only partial for low-molecular-weight heparins
Drugs with this mechanism (1)
- Protamine sulfate — Rapid heparin-reversal agent; excess dosing can itself impair coagulation.
Self-check
- What property allows heparin neutralization?
Opposite charges bind. - How complete is reversal of low-molecular-weight heparin?
Only partial.
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