Digoxin sequestrant
- Reverses life-threatening digoxin toxicity within minutes
- Antibody fragments bind digoxin
- Serum digoxin assays become meaningless after administration (bound drug is still measured)
- Hypokalemia as Na⁺/K⁺-ATPase activity returns
Drugs with this mechanism (1)
- Digoxin immune Fab — Digoxin-sequestering antibody fragments for life-threatening cardiac-glycoside toxicity.
Self-check
- Why do serum digoxin assays become misleading after immune Fab?
They still measure bound digoxin. - Which electrolyte abnormality can follow restored Na⁺/K⁺-ATPase activity?
Hypokalemia.
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