Cyanide sulfur donor
- Donates sulfur to rhodanese → converts cyanide to excretable thiocyanate
- A metabolic detox route, distinct from directly binding cyanide
Drugs with this mechanism (1)
- Sodium thiosulfate — Sulfur-donor cyanide antidote; also protects hearing during pediatric cisplatin therapy.
Self-check
- Which enzyme receives sulfur for cyanide detoxification?
Rhodanese. - What excretable product forms from cyanide?
Thiocyanate.
All mechanisms · Open Cyanide sulfur donor in the interactive console ↗