Acrolein binding (uroprotection)
A thiol decoy that meets the toxin in the urine
- Thiol donor binds acrolein, the bladder-toxic metabolite of cyclophosphamide/ifosfamide
- Binds acrolein into an inert thioether
- mesna (MESNEX) — 2-mercaptoethanesulfonate
- Neutralizes acrolein in the urinary tract → prevents hemorrhagic cystitis
- Acts in urine without affecting the antitumor effect
- Timed to the oxazaphosphorine doses (0, 4, 8 h); no effect on myelosuppression
Drugs with this mechanism (1)
- Mesna — Acrolein scavenger that protects the bladder during ifosfamide or cyclophosphamide treatment.
Self-check
- Which bladder injury is prevented by urinary acrolein neutralization?
Hemorrhagic cystitis. - Does acrolein sequestration prevent myelosuppression?
No.
All mechanisms · Open Acrolein binding (uroprotection) in the interactive console ↗