RyR1 blocker

Ryanodine receptor 1 blocker

Blocks sarcoplasmic calcium release — the malignant hyperthermia antidote
Also used for spasticity; hepatotoxicity with chronic use

Drugs with this mechanism (1)

Dantrolene — Blocks RyR1 calcium release in skeletal muscle; the antidote for malignant hyperthermia.

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