RXR agonist
Retinoid X receptor agonist
- RXR partners RAR, PPAR, LXR and thyroid receptors
- Broad transcriptional effects
- Central hypothyroidism and severe hypertriglyceridemia are expected
- RXR agonism suppresses TSH
- ⚑ Check TSH and free T4 before and during treatment
- Pancreatitis risk
- Teratogenic
- All retinoids require pregnancy precautions
Drugs with this mechanism (2)
- Alitretinoin — Pan-retinoid agonist (both RAR and RXR).
- Bexarotene — RXR-selective retinoid for cutaneous T-cell lymphoma; predictably disrupts thyroid and lipids.
Self-check
- How does RXR agonism affect TSH?
Suppresses it. - Which lipid abnormality is expected with RXR agonism?
Severe hypertriglyceridemia.
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