30S ribosome inhibitor
Bacterial 30S ribosomal subunit inhibitor
- Blocks bacterial protein synthesis at the 30S subunit
- Tetracyclines are bacteriostatic; aminoglycosides bactericidal
- Aminoglycoside nephrotoxicity and ototoxicity
Drugs with this mechanism (7)
- Amikacin — Aminoglycoside reserved for resistant Gram-negative and mycobacterial infection.
- Doxycycline — Versatile tetracycline for atypicals, tick-borne illness, and acne.
- Gentamicin — Aminoglycoside for serious Gram-negative infections; nephro- and ototoxic.
- Minocycline — Lipophilic tetracycline for acne and MRSA; dizziness and pigmentation.
- Neomycin — Aminoglycoside too toxic for systemic use; oral for gut decontamination, topical otherwise.
- Tetracycline — Prototype of its antibiotic class; broad but limited by resistance and food chelation.
- Tobramycin — Aminoglycoside favored for Pseudomonas, including inhaled use in cystic fibrosis.