RET/VEGFR inhibitor
RET and VEGFR kinase inhibitor
- ↓ tumor signaling and angiogenesis
- VEGF-pathway effects: hypertension, bleeding, impaired wound healing
Drugs with this mechanism (1)
- Vandetanib — RET/VEGFR inhibitor for medullary thyroid cancer; QT prolongation.
Self-check
- What tumor-supporting vascular process is reduced?
Angiogenesis. - Which repair process can VEGF-pathway inhibition impair?
Wound healing.
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