RAR agonist
Retinoic acid receptor agonist
- Drives cell differentiation
- Curative in acute promyelocytic leukemia
- Severe teratogen
Drugs with this mechanism (3)
- Acitretin — Systemic retinoid for severe psoriasis; alcohol converts it to long-lived etretinate.
- Tazarotene — Receptor-selective topical retinoid for psoriasis and acne; contraindicated in pregnancy.
- Tretinoin — All-trans retinoic acid; topical acne drug and systemic differentiation therapy for APL.
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