Pyridoxal kinase inhibitor
- Vitamin B6 is not converted to its active PLP form
- ↓ GABA synthesis → seizures
- The ginkgotoxin seizure mechanism
- Treated with pyridoxal-5-phosphate, bypassing the blocked kinase
Drugs with this mechanism (1)
- Ginkgotoxin — Ginkgo seed neurotoxin that blocks pyridoxal kinase, causing the pyridoxine-responsive seizures of raw ginkgo nuts.
Self-check
- Which neurotransmitter falls when pyridoxal kinase is blocked?
GABA. - What bypasses the blocked kinase in treatment?
Pyridoxal-5-phosphate.
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