PXR agonist
Pregnane X receptor agonist
- Induces CYP3A4 and P-glycoprotein → accelerates clearance of many co-administered drugs
- The mechanism behind St John wort interactions
Drugs with this mechanism (1)
- Hyperforin — St John's wort constituent; a potent PXR agonist driving CYP3A induction.
Self-check
- Which enzyme and transporter does PXR activation induce?
CYP3A4 and P-glycoprotein. - Which herb’s interactions are explained by PXR activation?
St John’s wort.
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