Purine synthesis inhibitor
- Impairs lymphocyte proliferation → immunosuppression
- Blocks de novo purine synthesis in lymphocytes
- Myelosuppression
- Amplified where thiopurine metabolism is impaired
Drugs with this mechanism (2)
- Azathioprine — Purine-synthesis immunosuppressant; toxicity tracks TPMT activity.
- Mercaptopurine — Active metabolite of azathioprine; TPMT and NUDT15 testing before dosing.
Self-check
- Why does impaired purine synthesis suppress immunity?
Impaired lymphocyte proliferation. - Which marrow toxicity accompanies purine-synthesis inhibition?
Myelosuppression.
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