Purine synthesis inhibitor

Blocks de novo purine synthesis in lymphocytes
Myelosuppression, amplified where thiopurine metabolism is impaired

Drugs with this mechanism (2)

Azathioprine — Purine-synthesis immunosuppressant; toxicity tracks TPMT activity.
Mercaptopurine — Active metabolite of azathioprine; TPMT and NUDT15 testing before dosing.

All mechanisms · Open the interactive console ↗