PTH receptor agonist
- Intermittent PTH-receptor stimulation favors osteoblasts → net bone formation
- Anabolic osteoporosis therapy
- Continuous exposure would instead resorb bone — the dosing schedule is the mechanism
- Transient hypercalcemia
Drugs with this mechanism (2)
- Abaloparatide — Bone-building PTHrP analog; anabolic osteoporosis agent.
- Teriparatide — Recombinant PTH fragment; anabolic (bone-building) osteoporosis drug.
Self-check
- Which cells are favored by intermittent PTH-receptor stimulation?
Osteoblasts. - What would continuous PTH exposure do instead?
Resorb bone.
All mechanisms · Open PTH receptor agonist in the interactive console ↗