Macromolecular biosynthesis inhibitor
Inhibition of bacterial, protozoal and fungal macromolecular biosynthesis
- Inhibits DNA, RNA, phospholipid and protein synthesis at once
- Broad antiprotozoal/antifungal action with ill-defined targets
- Nephrotoxicity and dysglycemia limit use
Drugs with this mechanism (1)
- Pentamidine — Antiprotozoal alternative for Pneumocystis pneumonia; parenteral toxicity is formidable.
Self-check
- Are the targets of this broad antiprotozoal action well defined?
No; ill-defined. - Which glucose-related toxicity limits use?
Dysglycemia.
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