PGE1 agonist
Prostaglandin E1 (EP receptor) agonist
- Gastric mucosal protection
- Protects against NSAID injury
- The uterotonic effect is useful in obstetrics and contraindicated in pregnancy otherwise
- Diarrhea, abdominal cramping
Drugs with this mechanism (1)
- Misoprostol — Prostaglandin for ulcer prevention, labor, and (with mifepristone) abortion.
Self-check
- PGE1 agonism protects gastric mucosa against which drug class?
NSAIDs. - How does pregnancy context change the role of the uterotonic effect?
Useful in obstetrics; contraindicated in pregnancy otherwise.
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