Prostacyclin IP receptor agonist
- Vasodilation and ↓ platelet aggregation → treats pulmonary arterial hypertension
- Headache, flushing, jaw pain, diarrhea
Drugs with this mechanism (3)
- Epoprostenol — Continuous IV prostacyclin for severe pulmonary arterial hypertension; interruption can be fatal.
- Selexipag — Oral prostacyclin-receptor agonist for pulmonary hypertension.
- Treprostinil — Prostacyclin analog for pulmonary hypertension; multiple delivery routes.
Self-check
- How does IP-receptor agonism affect platelet aggregation?
Decreases it. - Which GI adverse effect can IP-receptor agonists cause?
Diarrhea.
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