PPAR-delta agonist
- ↑ fatty-acid oxidation and altered lipid handling
- ↓ bile acid synthesis → ↓ cholestatic liver injury
Drugs with this mechanism (2)
- Elafibranor — Dual PPAR-alpha/delta agonist for primary biliary cholangitis after inadequate ursodiol response.
- Seladelpar — Selective PPAR-delta agonist for primary biliary cholangitis; also improves cholestatic pruritus.
Self-check
- How does PPAR-delta activation affect fatty-acid oxidation?
Increases it. - How does reduced bile-acid synthesis affect the liver?
Reduces cholestatic liver injury.
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