Thrombolytic

Plasminogen activator

Converts plasminogen to plasmin — clot lysis
Intracranial hemorrhage is the feared complication
Strict time windows in stroke

Drugs with this mechanism (2)

Alteplase — Thrombolytic for stroke and STEMI; the time window is everything.
Tenecteplase — Single-bolus thrombolytic; increasingly first-line in stroke.

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