PKC inhibitor

Protein kinase C (PKC) inhibitor

Hypothesized antimanic effect — the proposed basis for tamoxifen/endoxifen benefit in mania

Drugs with this mechanism (2)

Endoxifen — Tamoxifen's potent active metabolite — made by CYP2D6, which is why 2D6 inhibitors matter in breast cancer.
Tamoxifen — The classic breast-cancer SERM; a prodrug activated by CYP2D6.

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