PKC inhibitor
Protein kinase C (PKC) inhibitor
- A hypothesized antimanic mechanism — not established
- The proposed basis for tamoxifen/endoxifen benefit in mania
Drugs with this mechanism (2)
- Endoxifen — Potent active tamoxifen metabolite made by CYP2D6; hence 2D6 inhibitors matter in breast cancer.
- Tamoxifen — The classic breast-cancer SERM; a prodrug activated by CYP2D6.
Self-check
- Is PKC inhibition an established antimanic mechanism?
No; hypothesized. - Which two drugs have proposed antimanic benefit through PKC inhibition?
Tamoxifen and endoxifen.
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