PDE11 inhibitor
Phosphodiesterase-11 inhibitor
- Off-target inhibition of PDE11 in skeletal muscle and reproductive tissue
- Expressed in prostate and testis
- Tadalafil is only 14-fold selective for PDE5 over PDE11A1, the narrowest gap of the class
- The proposed basis of back pain and myalgia
- Back pain and myalgia distinguish tadalafil from the other PDE5 inhibitors
Drugs with this mechanism (2)
- Tadalafil (PAH) — Long-acting tadalafil formulation for pulmonary arterial hypertension.
- Tadalafil — Long-acting PDE5 inhibitor for erectile dysfunction and BPH; never combine with nitrates.
Self-check
- Which symptoms are proposed to arise from PDE11 inhibition?
Back pain and myalgia. - How selective is tadalafil for PDE5 over PDE11A1 in this deck?
Only 14-fold.
All mechanisms · Open PDE11 inhibitor in the interactive console ↗