PDE11 inhibitor

Phosphodiesterase-11 inhibitor

Off-target: expressed in skeletal muscle, prostate and testis, never the intended target
Tadalafil is only 14-fold selective for PDE5 over PDE11A1, the narrowest gap of the class
Proposed explanation for the back pain and myalgia that distinguish tadalafil from the other PDE5 inhibitors

Drugs with this mechanism (2)

Tadalafil (PAH) — Long-acting tadalafil formulation for pulmonary arterial hypertension.
Tadalafil — Long-acting PDE5 inhibitor for erectile dysfunction and BPH; never combine with nitrates.

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