PDE inhibitor

Phosphodiesterase inhibitor

Raises cyclic nucleotides — smooth muscle relaxation, inotropy or anti-inflammation by isoform
Headache and hypotension are class effects

Drugs with this mechanism (2)

Caffeine — The world's most-used stimulant; adenosine antagonist, OTC.
Pentoxifylline — Hemorheologic agent (PDE inhibitor) for intermittent claudication.

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