OX2 antagonist
Orexin-2 receptor antagonist
- ↑ REM sleep
- ➔ possible cataplexy
- ➔ possible sleep paralysis
- ➔ possible abnormal dreams
- ➔ MDD
- ➔ agitation in dementia
Drugs with this mechanism (4)
- Daridorexant — Dual orexin antagonist hypnotic with a short half-life for less next-day effect.
- Lemborexant — Dual orexin antagonist hypnotic.
- Seltorexant — Investigational selective orexin-2 antagonist for insomnia and depression.
- Suvorexant — Dual orexin antagonist for sleep-onset and sleep-maintenance insomnia.
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